Prepare the Beef: Freeze the beef for 1-2 hours to make slicing easier. Slice the beef against the grain into 1/8-1/4 inch thick strips.
Prepare the Marinade: Whisk together soy sauce, brown sugar, honey, rice vinegar, garlic, ginger, black pepper, red pepper flakes, sesame oil, Worcestershire sauce, and liquid smoke in a mixing bowl until well combined.
Marinate the Beef: Place beef strips into a resealable plastic bag or shallow dish. Pour marinade over the beef and massage it in. Refrigerate for at least 4 hours or overnight.
Preheat the Oven/Dehydrator: Preheat oven to 170°F (77°C) or follow dehydrator instructions.
Arrange the Beef: Pat beef strips dry with a paper towel, then arrange them in a single layer on the racks of your oven or dehydrator trays.
Dry the Jerky: Dry the jerky for 4-6 hours in the oven or 4-8 hours in a dehydrator, checking every 2 hours for doneness. Jerky is done when it bends without breaking.
Cool and Store: Let the jerky cool completely before storing in an airtight container or vacuum-sealed bag. Jerky can last up to 2 weeks at room temperature or 6 months in the freezer.